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MOTS-c supplementation augments acute exercise performance approximately 1215%, suggesting that elevated MOTS-c expression may improve acute metabolic responses to exercise

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Meanwhile, autophagy could be activated by rapamycin via PI3K/mTOR signaling pathway, and thus, protects hippocampal neurons from degeneration by decreasing the levels of prooxidants ( 142 , but also reveal the crucial role of Akt1 and PI3K in neuroprotection

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2005, 3: 28- Hanafy KA, Krumenacker JS, Murad F: NO, nitrotyrosine, and cyclic GMP in signal transduction