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The latter includes both central homeostatic (energy-intake-focused) and non-homeostatic (reward-focused) regulation of food consumption in the hypothalamus and nucleus of the solitary tract [[268], [269], [270], [271]], influenced by a relatively small amount of GLP-1 that crosses the blood-brain barrier and, more notably, GLP-1 modulation of vagal afferent neurons [268]

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Understanding that curve is particularly important for a multi-agonist like retatrutide, since its triple pathway activation may produce nonlinear effects that differ from those of single pathway agents

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doi: 10.1016/j.ydbio.2018.03.023 140