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"The rodent data is compelling but cannot substitute for proper clinical development" 14
Although no human studies have shown a negative impact on semen parameters, animal studies have shown damage to testicular sperm cells
In addition, DNA replication and DNA damage nucleotide excision repair (NER) pathways may provide an alternative mechanism to base excision repair (the primary mode of repair) to remove oxidized DNA damage in the sperm genome (David et al
doi: 10.1167/iovs.05-1139
In clinical settings it is sometimes used to treat overdoses
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