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This was done in the presence of the CI-linked substrates pyruvate (5 mM), malate (2 mM) and in the absence of ADP (2.5 mM) followed by the addition of cytochrome c (10 M) to test for the integrity of the mitochondrial outer membrane (cytochrome c control efficiency)

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4), whether disruption of this shuttle system directly licenses cuproptotic commitment remains an important open question

In den verfgbaren klinischen Forschungsdaten wurden keine Hinweise auf schwerwiegende hepatische, renale oder kardiovaskulre Nebenwirkungen berichtet

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