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Results: 19 patients (38%) reported depressive symptoms of any kind, while 31 patients (62%) showed no depressive symptoms (results are summarized in Table1)

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Unlike GLP-1 agonists such as semaglutide or tirzepatide, which work primarily through appetite suppression, AOD-9604 directly enhances fat metabolism at the cellular level through beta-3 adrenergic receptor modulation

Nat Rev Mol Cell Biol 2015;16, 393405, doi: Baar, M