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A sudden dark spot that keeps growing, changes shape, develops irregular borders, or bleeds requires prompt evaluation by a dermatologist

For instance, one study reported that although tirzepatide would avert 45 609 obesity cases (95% uncertainty interval (UI): 45 092 - 46 126) per 100 000 individuals and semaglutide would avert 32 087 cases (95% UI: 31 292 - 32 882) per 100 000 individuals, their respective incremental cost-effectiveness ratios in the United States were $197 023 per QALY and $467 676 per QALY in the US

Citations: Centers for Disease Control and Prevention

Anecdotal reports suggest that lowering the dose can help resolve fatigue while maintaining the positive weight-loss benefits

Most people start with 200 mg to 400 mg daily

Agomelatine does pose a risk of liver injury (Freiesleben and Furczyk, 2015), and the mechanism underlying agomelatine-induced liver injury appears to be idiosyncratic (Gahr et al., 2013)