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Simultaneously, angiogenesis-related factors induce macrophage polarization toward the M2 phenotype, thereby leading to the development of an immunosuppressive tumor microenvironment (TME)

33 , 34 After oral administration, absorption of glutathione is very poor mainly due to hydrolysis by intestinal and hepatic -glutamyltransferase as mentioned above, and for that reason, most therapeutic approaches using the oral route struggle to achieve results and the patients seek less safe treatments like intravenous treatment often under uncontrolled situations which may not be medically supervised, in some countries

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