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Biomolecules & therapeutics, 33(1), 117128

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The mean rate of eGFR decline was -1.4 per year in the combined tirzepatide groups and -3.6 per year in the insulin group (between-group difference 2.2 [95% CI 1.6 to 2.8]) with a greater benefit in participants with eGFR 500mg/dl the use of bile acid sequestrants is contraindicated (424)

However, some people have complained of diarrhoea, nausea, gastrointestinal pain, vomiting, headaches, and trouble sleeping

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Additional medical conditions The BMI and lifestyle requirements are both non-negotiable for Wegovy coverage, but on top of that, patients must meet one of the following requirements: Other weight loss drugs on the VA formularylike naltrexone/bupropionmust not be tolerated, not successful (less than 5% weight reduction), or medically inadvisable (with rationale)