436 Recent work reveals that some Zur proteins harbor a pair of regulatory Zn II sites distinct from the central HHxHx 2 Cx 2 C motif ( vide supra ) that stabilizes an oligomeric assembly of three or more Zur dimers on the promoters of genes encoding cognate metal efflux transporters, leading to RNA polymerase recruitment and activation of transcription when metal levels become very high
One should consider the primary phase lesion and hemorrhaging that results from mechanical damage during SCI as well as the secondary phase lesion that lasts several hours or even several months and is accompanied by edema, hemorrhage, inflammation, and cytotoxic edema [44,45,46,47] and may extend to the white matter area and lead to white matter degeneration and damage [48, 49]
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