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The affected cells look normal under light microscopy but showed pathological changes including loss of microvilli under electron microscopy.5 In guinea pigs, macrophages are most abundant in the caecum, decreasing towards the rectum

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When tissue is damaged, the microvascular endothelial cells in the surface layer of the vessels are activated by pro-angiogenic factors such as hypoxia/hypoxia tension and vascular endothelial growth factor (VEGF)

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