Khezri et al
However, although anti-inflammatory effects were obvious in the liver, no improvement of LPS-induced sickness behavior in mice was observed by a short pretreatment with SFN (Townsend and Johnson, 2017)
5).17 The main described causes are physiological aspects (racial melanonychia and pregnancy), mechanical trauma, post-inflammatory melanonychia (post-inflammatory hyperpigmentation), local infections (fungal or bacterial), drug-induced melanonychia (hydroxyurea, tetracyclines, amlodipine, psoralens, zidovudine or some chemotherapeutic agents, mainly cyclophosphamide, doxorubicin, and capecitabine), systemic diseases (hemosiderosis, HIV, porphyria, alkaptonuria, Addison disease, and Cushing syndrome), specific syndromes (Laugier-Hunziker-Baran, and Peutz-Jeghers syndromes), iatrogenic (phototherapy), and associated with keratinocyte nail tumors (onychomatricoma, onychocytic matricoma, onychopapilloma, and Bowen disease).17,21,2426 Melanocytic activation is usually asymptomatic, and dermoscopy of the nail plate surface reveals, in the majority of cases, a gray background color associated with parallel, thin, and regular lines.17,27,28 However, in individuals with phototypes IV, V, and VI, it may manifest as a brown or black discoloration (Fig
For significant pigmentation concerns, consulting a dermatologist is always the right first step
The therapy was shown to be safe, well tolerated and possibly beneficial for symptoms
Application G 1081 (OTTO) Glutathione reduced, 99% Cas 70-18-8 - used for recombinant protein purification with GST-tag
