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5.7 Acute Kidney Injury Due to Volume Depletion There have been postmarketing reports of acute kidney injury, in some cases requiring hemodialysis, in patients treated with GLP-1 receptor agonists [see Adverse Reactions (6.2)]

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Taken together, the present results support the idea that L-carnitine induces activation of the AKT pathway, and inhibits the TNF--induced increase in MAFbx expression by decreasing FOXO3a protein expression and promoting FOXO3a phosphorylation