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Head-to-head comparison While there haven't been direct studies comparing these two medications, meta-analyses examining multiple studies suggest semaglutide (Ozempic/Wegovy) produces significantly greater weight loss than phentermine

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By 2030, scientists predict it will become the second-leading cause of cancer death

Pharmacological management of obesity: an endocrine society clinical practice guideline

In addition, studies in which weight loss was greater during treatment than in the control group and studies in which lifestyle interventions were continued observed significant weight gain after drug discontinuation

34,51 Impact of Weight Reduction Research indicates a substantial similarity in how certain drugs reduce weight in both rodents and humans, specifically with drugs like phentermine/topiramate and others, including orlistat