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Cellular and molecular mechanisms and effects of berberine on obesity-induced inflammation

Figure 1 Mitochondria dynamics balanced with biogenesis and mitophagy Mitochondria continuously undergo a cycle of production (biogenesis), morphology (fusion/fission), and degradation (mitophagy)

Sulfonylureas such as glibenclamide exploit this mechanism therapeutically, and recent evidence indicates that glibenclamide also agonizes the TRPA1 ion channel, suggesting previously unrecognized interactions with sensory ion channels [19]

Liraglutide improves liver microvascular dysfunction in cirrhosis: evidence from translational studies

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These mechanisms remain the subject of ongoing laboratory and preclinical research