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doi:10.1001/archderm.1994.01690060057005 8

doi: 10.1016/j.glohj.2020.01.004

This distinction is key when comparing their mechanisms and long-term impacts

Too much signal and the doseresponse curve flattens - you spend more money and expose yourself to more side effects for no extra benefit

doi: 10.1038/s41573-021-00320-3 39 SinghMKotnisAJadejaSDMondalAMansuriMSBegumR

Moles that get crusty, painful, become itchy or bleed A mole that becomes crusty or bleeds should be reviewed as the visual changes can be markers of underlying changes within the mole