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A secondary analysis of this metric was completed after stratifying patients by overweight status

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GLP-1 receptor agonists originally developed for type 2 diabetes are now approved by the Therapeutic Goods Administration (TGA) for the treatment of obesity

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Applying REWIND cardiovascular disease criteria to SUSTAIN 6 and LEADER (REWIND trial reference)

4 In a parallel 36-week phase 2 obesity study, once-daily oral orforglipron produced dose-dependent weight reductions reaching a mean of about 14.7% at the top dose, with gastrointestinal effects nausea, constipation, diarrhea as the dominant, mostly mild-to-moderate adverse events, concentrated during dose escalation