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Both remain in phase 3 clinical development programs [16]: Cagrilintide Status: Phase 3 trials ongoing for CagriSema (cagrilintide + semaglutide combination) Expected approval timeline: 2027-2028 for the combination product Monotherapy development pathway unclear Retatrutide Status: Phase 3 trials initiated in 2024-2025 Monotherapy development for obesity and metabolic dysfunction Expected approval timeline: 2028-2029 if trials succeed This regulatory status means any use of these compounds, whether individually or in cagrilintide dosage with retatrutide combinations, occurs in research contexts or through off-label prescribing once (if) individual approvals are obtained

Overview It has long been known that one way to obtain a pool of bioavailable Fe II required for protein metalation in bacterial cells is to store it in intracellular compartments, notably heme-based bacterioferritins, ferritins, or in mini-ferritins, derived from the superfamily of DNA-binding proteins from starved cells (Dps), all of which are protein-coated biomineralized compartments of Fe II and Fe III

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et al., 2021