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We describe the inward-facing structure as substrate-free rather than apo, as we observe weak, non-proteinaceous density in the cleft between the two domains (Supplementary Fig

of his parents, though the boy may have other qualities that surpass those of his parentshe may be handsome, charming, athletic, graceful. McHugh sees his job as trying to get the parents to forget about adjusting him to their aims with medication or anything else. When I spoke with him on the phone, McHugh expanded on this point: Maybe its wrong-footed trying to fit people into the world, rather than trying to make the world a better place for people