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IGF-I signaling is important in skeletal muscle maintenance and repair IGF-I can reverse various muscle wasting conditions in experimental models The potential therapeutic effect of novel IGF-I formulations and biodegradable IGF-I variants must be explored in clinical trials Acknowledgements This work was supported by the project for the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

The endogenous peptide hormone GLP-1 binds to the GLP-1 receptor and regulates glucose levels and satiety signals

The colon was divided into six parts, including the cecum, ascending colon, transverse colon, descending colon, sigmoid colon and rectum

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The most common GLP-1 side effects are headaches, nausea, and gastrointestinal issues

Annu Rev Pharmacol Toxicol 1983;23:193215