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Biomed Pharmacother 2022;145:112412

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These were three phase three trial results that were studied of individuals with Type 2 diabetes

Two possibilities explain the animal oral data: Local action without systemic absorption: BPC-157 at high luminal concentrations acts directly on GI epithelium, submucosal vessels, and enteric neurons without requiring absorption into the bloodstream

These reports raised concerns, but so far larger studies and FDA evaluations have not confirmed a clear increase in risk

In addition, electron-dense filaments and myelin-like structures in the mitochondrial matrix that indicate cell injury were occasionally detected in JVS mice