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Dormancy is further stabilized by intrinsic regulators such as lncRNA NR2F1-AS1, which regulates stemness to prevent metastatic activation, and laminin-211 from the astrocytes in the brain, which maintains quiescence through dystroglycan signaling (163)

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In February 2023, the FDA gave Priority Review to Regenerons investigational antibody, which works by binding to the C5 complement factor, thereby disrupting the complement cascade and preventing associated diseases

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