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Cancer cells were sensitive to GGsTop when grown in cystine-free with GSH-supplemented conditions, but this increased sensitivity was reversed when cells were provided with cysteinylglycine, the product of GGT-mediated GSH catabolism (Fig

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This accumulation ratio is important for understanding what happens when you stop: it takes longer to reach "zero" than the simple half-life calculation might suggest because you are clearing accumulated drug, not just the final dose

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Cenicriviroc treatment for adults with nonalcoholic steatohepatitis and fibrosis: Final analysis of the phase 2b CENTAUR study