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Some of the negative effects of high homocysteine levels are modulated by the PON1 genotype.[ref] BLMH and BPHL are additional enzymes that can also metabolize homocysteine-thiolactone.[ref] Higher levels of homocysteine-thiolactone are also found in chronic inflammatory conditions, such as rheumatoid arthritis, inflammatory eye disease, and AMD.[ref][ref][ref] Lets take a look at why high homocysteine levels cause problems in the body, and then well look at genetic variants in the above cycles that can affect homocysteine levels when combined with dietary choices

If you're planning pregnancy and suspect your levels might be low, it's worth asking your GP for a 25-hydroxy vitamin D blood test before increasing your intake, particularly above 1,000 IU

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Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial