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13 Notably, these glucose-dependent modulatory effects on glucagon secretion appear to be diminished or absent in individuals with T2DM

It increases insulin release when blood sugar is high and lowers the amount of sugar that the liver makes

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doi: 10.1006/taap.1999.8833

CYP2D6 The CYP2D6 enzyme is critically involved in the metabolism of approximately 20-25% of all developed drugs and more than 48 different clinical substrates (drugs) for this enzyme have been identified, which include -blockers, antidepressants, opioid analgesics, antiarrhythmics, and antipsychotics