Journal of Clinical Medicine, 5 (4), 48
As its predicted GLP-1 use will continue to rise in OSA patients, a common topic in discussions, according to Peters, is how GLP-1s might affect the use of other sleep apnea therapies, like CPAP, oral appliances, and hypoglossal nerve stimulation
Patients were reviewed at least every 6 months over the first 36 months of the trial to assess for the development of LRE including liver related death, hepatocellular carcinoma, large varices requiring therapy, ascites, spontaneous bacterial peritonitis and encephalopathy
These findings suggest that the additional GCG agonism in cotadutide provides direct metabolic benefits to hepatocytes beyond those achievable through GLP-1 receptor activation alone, even when caloric restriction is matched [43]
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