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Immunofluorescence staining for protein expression (Col-2, MMP-13, p16 ink4a , and HMGB-1) was performed following our previously reported methods [38, 40]

Zum einen oxidiert das Glutathion mit einer Halbwertszeit von unter zwei Minuten, sodass es zwar im Blut, nicht aber in den Zellen ankommt, wo es bentigt wird

Nevertheless, recent investigations by McMullen et al

The density of BrdU+/Prox1+ cells showed a tendency of reduction in DG-NR1KO mice, but it was not significant ( p = 0.070, t (8.385) = 2.079, n = 7 control and 9 DG-NR1KO mice, respectively, independent-sample t test, two-tailed

From there, the trial product estimand and the treatment policy estimand were used to assess the efficacy of the treatment in all randomly assigned participants