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Alternatively, methylene-THF may be oxidised to formyl-THF and diverted to the purine synthesis pathway, or reduced to methyl-THF which participates in the formation of methionine, and ultimately S -adenosyl methionine, a universal methyl group donor

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10.1016/j.pbb.2013.12.019 145 PengW.LiP.LingR.WangZ.FengX.LiuJ.et al (2022)

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Although PPV was considered an attractive strategy for PCa, and even after successful phase II trials, the phase III trial of 310 patients with mCRPC receiving docetaxel found no survival advantage over PBO (HR 1.04