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Large-scale clinical trials, such as the SUSTAIN-6 trial, found that semaglutide significantly reduced the risk of major adverse cardiovascular events (MACE), including heart attacks and strokes, in people with type 2 diabetes and high cardiovascular risk

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Kovatcheva-Datchary and colleagues [127] revealed that after consuming a fiber-rich diet for three days, a high Provetella / Bacteroides ratio is linked to an improved response to postprandial glucose metabolism

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Understanding this physiological reality helps frame appropriate expectations and guides strategies to optimize body composition during treatment

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