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Although our synthesis shows increased gastrointestinal AEs and treatment discontinuation related to AEs, these challenges can generally be managed in practice through low-dose initiation, gradual up-titration, and regular monitoring 49

[PMC free article: PMC3569089] [PubMed: 23040069] 524

Xu, B., Yang, M., Li, Z., Zhang, Y., Jiang, Z., Guan, S., et al

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