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[DOI] [PubMed] [Google Scholar] McClean PL, Hlscher C

Semaglutide's mechanism involves slowing gastric emptying, enhancing glucose-dependent insulin secretion, and reducing appetite through central nervous system pathways

Given its strong weight-loss performance, Orforglipron is expected to capture a meaningful share of this expanding market

[10] [11] Phase 2 trial data published in the New England Journal of Medicine in 2023 (Jastreboff et al.) demonstrated substantial effects on body weight and metabolic parameters, though the full benefitrisk profile is still being established in ongoing Phase 3 trials

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The American Heart Association and the Heart Failure Society of America note that GLP-1R agonists can decrease systemic inflammation and platelet aggregation, contributing to their cardiovascular benefits [101]