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This trend is associated with substantial increases in morbidity and mortality, driven by complications including type 2 diabetes (T2D), metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular disease

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Some research suggests they may help in early disease stages or prolong remission

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Indeed, phase 3 trials are evaluating retatrutide in populations with T2D, OSA, knee OA, CKD and cardiovascular disease who may particularly benefit