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Conventional DMARDs (e.g., methotrexate, leflunomide, sulfasalazine): Methotrexate slows joint damage and suppresses inflammation but causes hepatic toxicity and bone marrow suppression, leading to 30% treatment discontinuation within one year (8)

Quality Assurance in Peptide Research Regardless of the molecule chosen, the validity of research findings depends entirely on the quality of the compound

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In addition, activating GLP-1R protected mitochondria against the TGF-1 + IL-1-induced increase in oxidative phosphorylation in fibroblasts