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1 GLP-1 is secreted from endocrine cells in the epithelium of the small intestine thatexpress the proglucagon gene, the so-called L cells

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For example, microbiome genome-wide association studies (mGWAS) have identified that variants of different genes (for example, VDR , LCT , NOD2 , FUT2 , and APOA5 ) that are associated with distinct gut microbiome compositions

For mild side effects, staying hydrated and eating smaller, more frequent meals can help alleviate some gastrointestinal discomfort

GLP-1 has also been shown to protect beta cells from apoptosis and stimulate beta-cell proliferation [10, 11]

Procedures were approved by the UTSW Institutional Animal Care and Use Committee (IACUC) beforehand (Protocols# 2016-101605 and 2017-101994)