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Adipocytes exposed to metabolic or oxidative stress secrete neutrophil-recruiting chemokines such as CXCL1 and CXCL2, along with dysregulated adipokines (leptin, resistin, visfatin), which directly prime neutrophils for enhanced reactive oxygen species (ROS) production and NET formation [30]
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71 While these findings suggest that GLP-1RAs can reach brain tissue by passive diffusion across the BBB, other research has shown that liraglutide could only enter the brain by binding to the central GLP-1 receptor