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This suggests that GLP-1 RAs may be most appropriate for adolescents with established obesity who have not responded to comprehensive lifestyle interventions
While not a direct side effect, some women have reported GLP-1 missed period incidents, often after changes in dosing
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These therapies support metabolic health by improving insulin sensitivity, stabilizing blood sugar, reducing appetite, and promoting consistent fat loss
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Accordingly, we encourage the adoption of GLP-1RA plus SGLT2i combination therapy in patients with T2DM and established atherosclerotic cardiovascular disease (ASCVD) or multiple risk factors for ASCVD (i.e., age 55 years, overweight/obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria)
