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Ongoing research is probing novel applications of GLP-1 agonists beyond diabetes and obesity from potential use in metabolic dysfunction-associated steatohepatitis (MASH) to trials investigating neuroprotective effects in conditions like Parkinsons and Alzheimers disease, though the 2025 phase 3 trials in both conditions failed to show clinical benefit ( [24] ) ( [25] )

The weight-loss medication landscape has shifted dramatically

International Cancer Genome Consortium, Toronto

M.GenuthS.LachinJ.ClearyP.CroffordO.et al (1993)

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Potential for Thyroid Dysfunction Concerns have been raised regarding the potential for thyroid dysfunction associated with long-term use of GLP-1 agonists