Hair thinning was reported as a side effect in some clinical trials of GLP-1 drugs, says Anthony Rossi, MD, a dermatologist and skin cancer surgeon at Memorial Sloan Kettering Cancer Center in New York City, who was not involved in the study
95,96 Pharmacological agents such as GLP-1 RAs mimic endogenous GLP-1 regulatory activities, aiding in T2D management by increasing the incretin effect, postprandial insulin release, increased satiety, and decreased glucagon secretion, thus improving glycemic control
Others may not notice a significant change in energy levels during treatment
Taken together the anti-cancer effect of biguanides is being studied in several types of cancer suggesting the potential repurpositioning not only of the anti-diabetics, but also of numerous other biguanides-related compounds
The average weight loss in the volunteers was 2.3kg (1 lb) compared to only 0.5kg in untreated control subjects
The improvement in HbA 1c following GLP-1 RA may primarily be driven by weight loss [50], but the mechanism may be more nuanced in individuals with type 1 diabetes and normal body weight
