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Glucose tolerance and insulin secretion have been investigated in patients with different thyroid status and experimental hypo- and hyperthyroid animal models, but not yielding a consistent explanation, which is likely due to the severity or duration of thyrotoxicosis or hormone treatment

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JAMA Netw Open 4(1):e2033457 [DOI] [PMC free article] [PubMed] [Google Scholar] 65.Kanbay M, Siriopol D, Copur S, Hasbal NB, Guldan M, Kalantar-Zadeh K et al (2024) Effect of bimagrumab on body composition: a systematic review and meta-analysis

In clinicals trials which have a primary endpoint - weight change from baseline, would dose reduction at a later stage of treatment period impede anyhow assessment of weight-loss potential

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Additionally, much of the research has focused on individuals with metabolic comorbidities, which leaves unanswered questions about the effectiveness of GLP-1 RAs in different populations