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Traditional hormonal avenues of treatment are also explored with repurposed medicines, like progestogens (two), GnRH antagonists (one) and other gynaecological medications such as fezolinetant, marketed for treatment of menopause related vasomotor symptoms (in Phase II), and three drugs initially developed for treating breast cancer (tamoxifen, raloxifene, letrozole)

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It is a major driver of liver disease, cardiovascular problems, and various forms of cancer

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Using IPA-based pathway analysis, the authors identified LXR/RXR activation, acute-phase response signaling, and production of reactive oxygen species and nitric oxide in macrophages as significant pathways (Additional file 1)