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The folding of the peptide, usually as an -helix, additionally assists it in maintaining its shape and binding with high affinity to its targets

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The replacement of original Gs -helical domain (AHD, V65-L203) with that of human Gi1 (G60-K180) provided the binding site for Fab_G50, an antibody fragment used to stabilize the rhodopsin-G i complex 49