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One directly affects the somatotropic cells of the anterior pituitary, itself inhibiting further release of GH, whilst the other affects GH releasing hormone and somatostatin release from the hypothalamus to reduce the secretion of GH

The addition of glucagon receptor agonism introduces theoretical concerns about hepatic glucose output, though no clinically significant hyperglycemia was observed

Using them together aims to provide the benefits of both sustained exposure and sharp pulses, potentially leading to superior outcomes in fat loss, muscle growth, and skin rejuvenation

A generic for dulaglutide (Trulicity) could be available at the end of 2027

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Together they promote injury recovery and healing