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doi: 10.1016/S0140-6736(25)02165-8

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Moreover, extended passaging often promotes the selective expansion of dominant clones, resulting in the loss of rare but clinically significant CSC subpopulations

2008;29(2 Suppl):S143-172

This natural progression means patience is essentialrapid initial losses often slow, which is normal and healthy biology, not a sign of treatment failure