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In response to OS, different metabolites oxidize highly reactive cysteine residues in KEAP1, inducing a conformational change in the KEAP1-NEDD8-CUL3-RBX1-E3 ubiquitin ligase complex, with an improper orientation of Lys residues on NRF2 [122, 158]
22 , 23 In a series of publications, the Truscott laboratory has identified a number of kynurenines and derivatives that are present in the human lens, they have described the pathways whereby these compounds are produced, and they have shown that these UV filters absorb ultraviolet radiation that otherwise could have detrimental photochemical effects on the lens and retina
Current clinical management predominantly centers on the reduction of intraocular pressure (IOP) to decelerate disease progression, yet it remains ineffective in preventing RGC death
Finally, we have recently shown that the wound-induced switch to weak keratinocyte adhesion fails in chronic wounds from aged patients [156]
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