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2.1.1 Glutathione peroxidase 4 Antioxidant defense systems, such as GPX4, play a critical role in protecting cells from ferroptosis (146)

The most common side effects of Wegovy are also GI-related, including nausea , diarrhea, vomiting, constipation , and abdominal pain

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ROS, generated by mitochondria, NADPH oxidase, or exogenous sources, disrupt Keap1, allowing Nrf2 to enter the nucleus and induce antioxidant genes for cytoprotection

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doi: 10.1016/j.redox.2024.103211 Summary Keywords ferropotosis, AKI, CKD, renal tumor, therapeutic translation, oxidative stress, iron metabolism Citation Luo Y, Long M, Wu X and Zeng L (2025) Targeting ferroptosis: novel therapeutic approaches and intervention strategies for kidney diseases