chicory root glp 1 Intrinsic fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity GLP-1 Plus pack of 60

Namely, high-fat, calorie-dense foods should be avoided, as they can contribute to weight gain

1 Findings appear in The Lancet Diabetes & Endocrinology

1 Not well-known until recently, this incretin effect is severely reduced in patients with type 2 diabetes (T2DM) and has been therapeutically exploited to develop an entirely new class of antidiabetic drugs

These findings suggest that GLP-1RAs may target GLP-1R in EAT to regulate local adipogenesis, energy utilization, and cellular phenotype, thereby influencing cardiovascular health (Figure 2)

Y.LeibelR

SURMOUNT-2 later confirmed tirzepatide's glucose-lowering effect in people who already had type 2 diabetes [7], but SURMOUNT-1 is the dataset that matters for the "before prediabetes" question