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However, in order to have biological activity, T4 and T3 must cross the cellular membrane from the serum into the target cells

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[3] However, the precise contribution of each receptor pathway to gastrointestinal tolerability in a triple agonist has not been fully characterised in humans, and this attribution should be regarded as informed by class-effect data rather than confirmed mechanism

Garcia-Haro L, Garcia-Gimeno MA, Neumann D, Beullens M, Bollen M, Sanz P

Therapeutic potential of hepcidin - the master regulator of iron metabolism

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