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Ghrelin may stimulate angiogenesis, or the growth of new blood vessel networks

The body struggles to reduce dehydroascorbate (oxidised vitamin C) without enough glutathione

Less obvious is chronic inability to absorb B12, which often results from long-term antacid use, Crohns disease, gastric bypass, atrophic gastritis, and pernicious anemia

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It is also important to ensure adequate intake of vitamin B12 and B6 , which collaborate with vitamin B9 in the methylation cycle and may help to minimize the adverse effects of reduced metabolism due to decreased MTHFR enzyme activity