Mitochondrial dysfunction and therapeutic strategies across neurodegenerative diseases The following sections systematically examine the manifestations of mitochondrial dysfunction across major neurodegenerative disorders, ranging from widespread central nervous system diseases to instructive optic neuropathies
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Cancer cells were sensitive to GGsTop when grown in cystine-free with GSH-supplemented conditions, but this increased sensitivity was reversed when cells were provided with cysteinylglycine, the product of GGT-mediated GSH catabolism (Fig
Heavy metal detoxification: Glutathione conjugation is a primary pathway for detoxifying mercury, arsenic, cadmium, and lead
In the liver, TMA is converted to TMAO catalyzed by FMO3 (31)
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