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The focus on pharmacological interventions may overshadow the importance of lifestyle changes, such as diet and exercise, which are crucial for sustainable weight management
More serious but less common risks include pancreatitis, gallbladder disease, and in people with type 2 diabetes potential worsening of diabetic retinopathy
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Dose escalation, timing relative to large meals, existing reflux disease, and vagal or diabetic neuropathy each affect the strength with which gut signals reach the brainstem
The design of isoform- and hepatocyte-specific THR modulators offers a mechanistic basis for liver-targeted antifibrotic therapies, aiming to optimize efficacy while minimizing systemic adverse effects ( In clinical studies, Resmetirom (MGL-3196), the first THR agonist approved by the U.S
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