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13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [2-, 11-, and 30-fold the maximum recommended human dose (MRHD) of 2 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (1-, 2-, and 7-fold MRHD) were administered to the females

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Step 3: Pharmacy Fulfillment and Delivery Once approved, prescriptions are routed to dispensing partners for fulfillment and delivery, which may vary by patient location and availability

This pulsatility matters because sustained GH elevation, rather than pulsatile release, is associated with greater receptor desensitization and a less favorable metabolic profile